19F imaging of cerebral blood oxygenation in experimental middle cerebral artery occlusion: preliminary results

Eidelberg, D., Johnson, G., Tofts, P. S., Dobbin, J., Crockard, H. A. and Plummer, D. (1988) 19F imaging of cerebral blood oxygenation in experimental middle cerebral artery occlusion: preliminary results. Journal of Cerebral Blood Flow & Metabolism, 8 (2). pp. 276-281. ISSN 0271-678X

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Abstract

Fluorine (19F) nuclear magnetic resonance may be used to image cerebral perfusion in cats receiving perfluorocarbon blood substitutes. 19F relaxation times in these blood substitutes are dependent on oxygen tension (PO2) and may be used to calculate and spatially map cerebrovascular PO2 values in vivo. We have applied this noninvasive method to experimental middle cerebral artery (MCA) occlusion. Following MCA occlusion a perfusion defect is evident in the sylvian region, followed by the appearance of collaterals. Signal from the ipsilateral rete mirabilis is increased. Calculated cortical vascular PO2 values indicate a relative reduction in oxygenation in the ischaemic hemisphere. PO2 maps show a perfused hypoxaemic zone adjacent to the perfusion defect. These changes are partly reversed with reperfusion.

Item Type:	Article
Uncontrolled Keywords:	animals,brain chemistry,cats,cerebral arteries,constriction,fluorine diagnostic use,magnetic resonance spectroscopy,oxygen analysis
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User:	Pure Connector
Date Deposited:	07 Oct 2015 14:00
Last Modified:	15 Dec 2022 02:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54604
DOI:	10.1038/jcbfm.1988.58

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