Angiotensin-converting enzyme inhibitor-enhanced phase-contrast MR imaging to measure renal artery velocity waveforms in patients with suspected renovascular hypertension

Lee, Vivian S., Rofsky, Neil M., Ton, Anthony T., Johnson, Glyn, Krinsky, Glenn A. and Weinreb, Jeffrey C. (2000) Angiotensin-converting enzyme inhibitor-enhanced phase-contrast MR imaging to measure renal artery velocity waveforms in patients with suspected renovascular hypertension. American Journal of Roentgenology, 174 (2). pp. 499-508. ISSN 0361-803X

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Abstract

OBJECTIVE: We investigated the usefulness of phase-contrast MR imaging to measure renal artery velocity waveforms as an adjunct to renal MR angiography. We also examined whether an angiotensin-converting enzyme (ACE) inhibitor improves the diagnostic accuracy of waveform analysis. SUBJECTS AND METHODS: Thirty-five patients referred for MR angiography of renal arteries underwent non-breath-hold oblique sagittal velocity-encoded phase-contrast MR imaging through both renal hila (TR/TE, 24/5; flip angle, 30 degrees; signal averages, two; encoding velocity, 75 cm/sec) before and after i.v. administration of an ACE inhibitor (enalaprilat). We analyzed velocity waveforms using established Doppler sonographic criteria. A timing examination with a test bolus of gadolinium contrast material was performed to ensure optimal arterial enhancement during breath-hold gadolinium-enhanced three-dimensional gradient-echo MR angiography. RESULTS: MR phase-contrast waveform pattern analysis was 50% (9/18) sensitive and 78% (40/51) specific for the detection of renal artery stenosis equal to or greater than 60% as shown on MR angiography. Sensitivity (67%, 12/18) and specificity (84%, 42/50) increased slightly, but not significantly, after i.v. administration of an ACE inhibitor. Also, the accuracy of quantitative criteria such as acceleration time and acceleration index did not improve after the administration of ACE inhibitor. CONCLUSION: Renal hilar velocity waveforms, measured using non-breath-hold MR phase-contrast techniques with or without an ACE inhibitor, are insufficiently accurate to use in predicting renal artery stenosis.

Item Type:	Article
Uncontrolled Keywords:	0 (angiotensin-converting enzyme inhibitors),0 (contrast media) gv0o7es0r3,(enalaprilat) ,adult aged aged,80 and over angiotensin-converting enzyme inhibitors,diagnostic use blood flow velocity ,contrast media enalaprilat,diagnostic use false positive reactions female humans hypertension, renovascular,physiopathology magnetic resonance angiography,methods male middle aged renal artery,physiology sensitivity and specificity,pathology
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Depositing User:	Pure Connector
Date Deposited:	18 Sep 2015 10:32
Last Modified:	21 Oct 2022 01:15
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54448
DOI:	10.2214/ajr.174.2.1740499

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