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ToolsPomara, Nunzio, Crandall, David T., Choi, Steven J., Johnson, Glyn and Lim, Kelvin O. (2001) White matter abnormalities in HIV-1 infection: a diffusion tensor imaging study. Psychiatry Research, 106 (1). pp. 15-24. ISSN 0165-1781
Full text not available from this repository. (Request a copy)Abstract
Diffuse white matter pallor is the most frequent neuropathological feature of HIV-1 infection and has been found to be particularly prominent in the advanced stages of the disease. The purpose of this study was to determine whether subtle white matter abnormalities can be detected in medically stable, ambulatory HIV-1 patients, in vivo, using diffusion tensor imaging (DTI). DTI is a magnetic resonance imaging (MRI) technique that is uniquely suited for the study of subtle white matter abnormalities. DTI was performed in six HIV-1 patients and nine controls. The two groups were similar in age. Abnormal fractional anisotropy was found in the white matter of the frontal lobes and internal capsules of the HIV-1 patients, in the absence of group differences in mean diffusivity, computed proton density, and computed T2. DTI may be more sensitive than conventional MRI methods for detecting subtle white matter disruptions in HIV-1 disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | acquired immunodeficiency syndrome,virology adult anisotropy brain,pathology,virology,hiv-1 humans,magnetic resonance imaging male,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit |
| Depositing User: | Pure Connector |
| Date Deposited: | 17 Sep 2015 15:22 |
| Last Modified: | 21 Oct 2022 01:15 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/54445 |
| DOI: | 10.1016/S0925-4927(00)00082-2 |
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