Peritumoral diffusion tensor imaging of high-grade gliomas and metastatic brain tumors

Lu, Stanley, Ahn, Daniel, Johnson, Glyn and Cha, Soonmee (2003) Peritumoral diffusion tensor imaging of high-grade gliomas and metastatic brain tumors. American Journal of Neuroradiology, 24 (5). pp. 937-941. ISSN 1936-959X

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Abstract

BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) is an advanced MR technique that describes the movement of water molecules by using two metrics, mean diffusivity (MD), and fractional anisotropy (FA), which represent the magnitude and directionality of water diffusion, respectively. We hypothesize that alterations in these values within the tissue surrounding brain tumors reflect combinations of increased water content and tumor infiltration and that these changes can be used to differentiate high-grade gliomas from metastatic lesions. METHODS: DTI was performed in 12 patients with high-grade gliomas and in 12 with metastatic lesions. DTI measurements were obtained from regions of interest (ROIs) placed on normal-appearing white matter and on the vasogenic edema, the T2 signal intensity abnormality surrounding each tumor. RESULTS: The peritumoral region of both gliomas and metastatic tumors displayed significant increases in MD (P

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Related URLs:	https://www.ajnr.org/content/24/5/937
Depositing User:	Pure Connector
Date Deposited:	28 Sep 2015 13:56
Last Modified:	08 Aug 2023 09:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54434
DOI:

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