Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade

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Law, Meng, Yang, Stanley, Babb, James S., Knopp, Edmond A., Golfinos, John G., Zagzag, David and Johnson, Glyn (2004) Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. American Journal of Neuroradiology, 25 (5). pp. 746-755. ISSN 1936-959X

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Abstract

BACKGROUND AND PURPOSE: Relative cerebral blood volume (rCBV) and vascular permeability (K(trans)) permit in vivo assessment of glioma microvasculature. We assessed the associations between rCBV and K(trans) derived from dynamic, susceptibility-weighted, contrast-enhanced (DSC) MR imaging and tumor grade and between rCBV and K(trans). METHODS: Seventy-three patients with primary gliomas underwent conventional and DSC MR imaging. rCBVs were obtained from regions of maximal abnormality for each lesion on rCBV color maps. K(trans) was derived from a pharmacokinetic modeling algorithm. Histopathologic grade was compared with rCBV and K(trans) (Tukey honestly significant difference). Spearman and Pearson correlation factors were determined between rCBV, K(trans), and tumor grade. The diagnostic utility of rCBV and K(trans) in discriminating grade II or III tumors from grade I tumors was assessed by logistic regression. RESULTS: rCBV was significantly different for all three grades (P

Item Type:	Article
Uncontrolled Keywords:	adolescent adult aged aged,80 and over ,blood volume brain neoplasms,blood supply,pathology,physiopathology,capillary permeability ,cerebrovascular circulation child,preschool contrast media female glioma,physiopathology humans ,magnetic resonance imaging,methods male middle aged retrospective studies
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Related URLs:	http://www.ajnr.org/content/25/5/746.ful...
Depositing User:	Pure Connector
Date Deposited:	18 Sep 2015 14:20
Last Modified:	07 Mar 2023 11:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54425
DOI:

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