Advantages of parallel imaging in conjunction with hyperpolarized helium: a new approach to MRI of the lung

Lee, Ray F., Johnson, Glyn, Grossman, Robert I., Stoeckel, Bernd, Trampel, Robert and McGuinness, Georgeann (2006) Advantages of parallel imaging in conjunction with hyperpolarized helium: a new approach to MRI of the lung. Journal of Magnetic Resonance Imaging, 55 (5). pp. 1132-1141. ISSN 1522-2586

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Abstract

Hyperpolarized helium (3He) gas MRI has the potential to assess pulmonary function. The non-equilibrium state of hyperpolarized 3He results in the continual depletion of the signal level over the course of excitations. Under non-equilibrium conditions the relationship between the signal-to-noise ratio (SNR) and the number of excitations significantly deviates from that established in the equilibrium state. In many circumstances the SNR increases or remains the same when the number of data acquisitions decreases. This provides a unique opportunity for performing parallel MRI in such a way that both the temporal and spatial resolution will increase without the conventional decrease in the SNR. In this study an analytical relationship between the SNR and the number of excitations for any flip angle was developed. Second, the point-spread function (PSF) was utilized to quantitatively demonstrate the unconventional SNR behavior for parallel imaging in hyperpolarized gas MRI. Third, a 24-channel (24ch) receive and two-channel (2ch) transmit phased-array system was developed to experimentally prove the theoretical predictions with 3He MRI. The in vivo experimental results prove that significant temporal resolution can be gained without the usual SNR loss in an equilibrium system, and that the entire lung can be scanned within one breath-hold (approximately 13 s) by applying parallel imaging to 3D data acquisition.

Item Type:	Article
Uncontrolled Keywords:	06gf3gb41 (helium) administration, inhalation algorithms computing methodologies equipment design equipment failure analysis helium,administration & dosage,diagnostic use humans image enhancement,instrumentation,methods image interpretation, computer-assisted,methods imaging,methods information storage and retrieval,anatomy & histology magnetic resonance imaging,methods reproducibility of results sensitivity and specificity
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Depositing User:	Pure Connector
Date Deposited:	18 Sep 2015 11:08
Last Modified:	21 Oct 2022 01:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54386
DOI:	10.1002/mrm.20855

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