Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo

Rooney, William D., Johnson, Glyn, Li, Xin, Cohen, Eric R., Kim, Seong-Gi, Ugurbil, Kamil and Springer Jr, Charles S. (2007) Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo. Journal of Magnetic Resonance Imaging, 57 (2). pp. 308-318. ISSN 1522-2586

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Abstract

Brain water proton (1H2O) longitudinal relaxation time constants (T1) were obtained from three healthy individuals at magnetic field strengths (B0) of 0.2 Tesla (T), 1.0T, 1.5T, 4.0T, and 7.0T. A 5-mm midventricular axial slice was sampled using a modified Look-Locker technique with 1.5 mm in-plane resolution, and 32 time points post-adiabatic inversion. The results confirmed that for most brain tissues, T1 values increased by more than a factor of 3 between 0.2T and 7T, and over this range were well fitted by T1 (s)=0.583(B0)0.382, T1(s)=0.857(B0)0.376, and T1(s)=1.35(B0)0.340 for white matter (WM), internal GM, and blood 1H2O, respectively. The ventricular cerebrospinal fluid (CSF) 1H2O T1 value did not change with B0, and its average value (standard deviation (SD)) across subjects and magnetic fields was 4.3 (+/-0.2) s. The tissue 1/T1 values at each field were well correlated with the macromolecular mass fraction, and to a lesser extent tissue iron content. The field-dependent increases in 1H2O T1 values more than offset the well-known decrease in typical MRI contrast reagent (CR) relaxivity, and simulations predict that this leads to lower CR concentration detection thresholds with increased magnetic field.

Item Type:	Article
Uncontrolled Keywords:	adult algorithms body water,metabolism ,brain mapping,methods chi-square distribution humans image processing,computer-assisted magnetic resonance imaging,methods male middle aged
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Depositing User:	Pure Connector
Date Deposited:	21 Sep 2015 10:16
Last Modified:	21 Oct 2022 01:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54380
DOI:	10.1002/mrm.21122

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