Relative cerebral blood volume measurements of low-grade gliomas predict patient outcome in a multi-institution setting

Caseiras, Gisele B., Chheang, Sophie, Babb, James, Rees, Jeremy H., Pecerrelli, Nicole, Tozer, Daniel J., Benton, Christopher, Zagzag, David, Johnson, Glyn, Waldman, Adam D., Jäger, H. R. and Law, Meng (2010) Relative cerebral blood volume measurements of low-grade gliomas predict patient outcome in a multi-institution setting. European Journal of Radiology, 73 (2). pp. 215-220. ISSN 0720-048X

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Abstract

BACKGROUND/PURPOSE: The prognostic value of defining subcategories of gliomas is still controversial. This study aims to determine the utility of relative cerebral blood volume (rCBV) in predicting clinical response in patients with low-grade glioma at multiple institutions. MATERIALS AND METHODS: Sixty-nine patients were studied with dynamic susceptibility contrast-enhanced perfusion MRI at two institutions. The pathologic diagnoses of the low-grade gliomas were 34 astrocytomas, 20 oligodendroglioma, 9 oligoastrocytomas, 1 ganglioglioma and 5 with indeterminate histology. Wilcoxon tests were used to compare patients in different response categories with respect to baseline rCBV. Kaplan-Meier curve and log-rank tests were used to predict the association of rCBV with time to progression. RESULTS: At both institutions, patients with an adverse event (progressive disease or death) had a significantly higher baseline rCBV than those without (complete response or stable disease) (p value=0.0138). The odds ratio for detecting an adverse event when using rCBV was 1.87 (95% confidence interval: 1.14-3.08). rCBV was significantly negatively associated with time to progression (p=0.005). The median time to progression among subjects with rCBV>1.75 was 365 days, while there was 95% confidence that the median time to progression was at least 889 days among subjects with rCBV

Item Type:	Article
Uncontrolled Keywords:	brain tumours,perfusion,rcbv,outcome
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User:	Pure Connector
Date Deposited:	15 Sep 2015 10:32
Last Modified:	21 Oct 2022 01:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54365
DOI:	10.1016/j.ejrad.2008.11.005

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