Regulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinase

Martinsen, Anneloes, Dessy, Chantal and Morel, Nicole (2014) Regulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinase. In: UNSPECIFIED UNSPECIFIED, pp. 402-413.

Full text not available from this repository. (Request a copy)

Abstract

Smooth muscle myosin light chain kinase (MLCK) plays a crucial role in artery contraction, which regulates blood pressure and blood flow distribution. In addition to this role, MLCK contributes to Ca(2+) flux regulation in vascular smooth muscle (VSM) and in non-muscle cells, where cytoskeleton has been suggested to help Ca(2+) channels trafficking. This conclusion is based on the use of pharmacological inhibitors of MLCK and molecular and cellular techniques developed to down-regulate the enzyme. Dissimilarities have been observed between cells and whole tissues, as well as between large conductance and small resistance arteries. A differential expression in MLCK and ion channels (either voltage-dependent Ca(2+) channels or non-selective cationic channels) could account for these observations, and is in line with the functional properties of the arteries. A potential involvement of MLCK in the pathways modulating Ca(2+) entry in VSM is described in the present review.

Item Type: Book Section
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Pure Connector
Date Deposited: 18 Sep 2015 13:44
Last Modified: 22 Apr 2020 08:49
URI: https://ueaeprints.uea.ac.uk/id/eprint/54348
DOI: 10.4161/19336950.2014.950537

Actions (login required)

View Item View Item