Regulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinase

Martinsen, Anneloes, Dessy, Chantal and Morel, Nicole (2014) Regulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinase. In: UNSPECIFIED UNSPECIFIED, pp. 402-413.

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Abstract

Smooth muscle myosin light chain kinase (MLCK) plays a crucial role in artery contraction, which regulates blood pressure and blood flow distribution. In addition to this role, MLCK contributes to Ca(2+) flux regulation in vascular smooth muscle (VSM) and in non-muscle cells, where cytoskeleton has been suggested to help Ca(2+) channels trafficking. This conclusion is based on the use of pharmacological inhibitors of MLCK and molecular and cellular techniques developed to down-regulate the enzyme. Dissimilarities have been observed between cells and whole tissues, as well as between large conductance and small resistance arteries. A differential expression in MLCK and ion channels (either voltage-dependent Ca(2+) channels or non-selective cationic channels) could account for these observations, and is in line with the functional properties of the arteries. A potential involvement of MLCK in the pathways modulating Ca(2+) entry in VSM is described in the present review.

Item Type:	Book Section
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/25483...
Depositing User:	Pure Connector
Date Deposited:	18 Sep 2015 13:44
Last Modified:	15 Oct 2025 18:33
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54348
DOI:	10.4161/19336950.2014.950537

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