Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)

Arnemann, Joachim, Spurr, Nigel K, Wheeler, Grant N. ORCID: https://orcid.org/0000-0002-4335-8577, Parker, Andrew E. and Buxton, Roger S. (1991) Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP). Genomics, 10 (3). pp. 640-645. ISSN 1089-8646

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Abstract

We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hybrids with different contents of human chromosomes. From these data we were able to assign DGI to chromosome 18 (DSG), DGII/III to chromosome 9p (DSC), DPI/II to chromosome 6p21-ter(DSP), and DPIII to chromosome 7 (JUP).

Item Type:	Article
Uncontrolled Keywords:	animals,base sequence,chromosome mapping,chromosomes, human, pair 18,chromosomes, human, pair 6,chromosomes, human, pair 7,chromosomes, human, pair 9,cytoskeletal proteins,desmocollins,desmogleins,desmoplakins,desmosomes,genes,humans,hybrid cells,mice,molecular sequence data,polymerase chain reaction,rats,gamma catenin
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Cells and Tissues
Depositing User:	Pure Connector
Date Deposited:	11 Aug 2015 16:06
Last Modified:	19 Apr 2023 00:48
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54069
DOI:	10.1016/0888-7543(91)90446-L

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