Reversible DNA i-motif to hairpin switching induced by copper(II) cations

Day, Henry Albert, Wright, Elisé Patricia, MacDonald, Colin John, Gates, Andrew James ORCID: https://orcid.org/0000-0002-4594-5038 and Waller, Zoë Ann Ella (2015) Reversible DNA i-motif to hairpin switching induced by copper(II) cations. Chemical Communications, 51 (74). pp. 14099-14102. ISSN 1359-7345

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Abstract

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.

Item Type:	Article
Additional Information:	This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Science Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Molecular Microbiology Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry
Depositing User:	Pure Connector
Date Deposited:	14 Aug 2015 14:22
Last Modified:	25 Oct 2024 23:41
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54057
DOI:	10.1039/c5cc05111h

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