Tools
Tools
Penso-Dolfin, L, Wu, Taoyang 
ORCID: https://orcid.org/0000-0002-2663-2001 and Greenman, C
(2015)
The Combinatorics of Tandem Duplication.
Discrete Applied Mathematics, 194.
1–22.
ISSN 0166-218X
![[thumbnail of pdf]](https://ueaeprints.uea.ac.uk/style/images/fileicons/other.png) |
Other (pdf)
- Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (2MB) |
Preview |
PDF (greenman_DAM)
- Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (2MB) | Preview |
Abstract
Tandem duplication is an evolutionary process whereby a segment of DNA is replicated and proximally inserted. The different configurations that can arise from this process give rise to some interesting combinatorial questions. Firstly, we introduce an algebraic formalism to represent this process as a word producing automaton. The number of words arising from n tandem duplications can then be recursively derived. Secondly, each single word accounts for multiple evolutions. With the aid of a bi-coloured 2d- tree, a Hasse diagram corresponding to a partially ordered set is constructed, from which we can count the number of evolutions corresponding to a given word. Thirdly, we implement some subtree prune and graft operations on this structure to show that the total number of possible evolutions arising from n tandem duplications is $\prod_{k=1}^n(4^k - (2k + 1))$. The space of structures arising from tandem duplication thus grows at a super-exponential rate with leading order term $\mathcal{O}(4^{\frac{1}{2}n^2})$.
| Item Type: | Article |
|---|---|
| Additional Information: | 22 Pages, 7 Figures, 1 Table |
| Uncontrolled Keywords: | combinatorics,tandem duplication,posets,rearrangements,evolution |
| Faculty \ School: | Faculty of Science > School of Computing Sciences University of East Anglia > Faculty of Science > Research Groups > Computational Biology (subgroups are shown below) > Analysis and models of genomic variation Faculty of Science > School of Natural Sciences |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Jul 2015 22:48 |
| Last Modified: | 21 Oct 2022 14:32 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/53707 |
| DOI: | 10.1016/j.dam.2015.05.014 |
Actions (login required)
 |
View Item |