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ToolsFrassetto, L. A., Hardcastle, A. C., Sebastian, A., Aucott, L., Fraser, W. D., Reid, D. M. and Macdonald, H. M. (2012) No evidence that the skeletal non-response to potassium alkali supplements in healthy postmenopausal women depends on blood pressure or sodium chloride intake. European Journal of Clinical Nutrition, 66 (12). pp. 1315-1322. ISSN 0954-3007
Full text not available from this repository. (Request a copy)Abstract
In vitro studies demonstrate that bone is degraded in an acidic environment due to chemical reactions and through effects on bone cells. Clinical evidence is insufficient to unequivocally resolve whether the diet net acid or base load bone affects breakdown in humans. Increasing dietary salt (sodium chloride, NaCl) mildly increases blood acidity in humans and in rats with increased sensitivity to the blood pressure effects of salt, whereas increased potassium (K) intake can decrease blood pressure. Blood pressure responses to NaCl or K may potentially be a marker for increased bone turnover or lower bone mineral density (BMD) in women at higher risk for osteoporosis and fracture.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adult,aged,aged, 80 and over,alkalies,biological markers,blood pressure,bone density,bone resorption,california,chlorides,diet,dietary supplements,female,humans,middle aged,osteoporosis, postmenopausal,potassium, dietary,retrospective studies,scotland,sodium,sodium chloride, dietary,spine |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Jul 2015 22:22 |
| Last Modified: | 19 Oct 2023 01:27 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/53246 |
| DOI: | 10.1038/ejcn.2012.151 |
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