Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues

Leco, Kevin J., Apte, Suneel S., Taniguchi, Gary T., Hawkes, Susan P., Khokha, Rama, Schultz, Gilbert A. and Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 (1997) Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues. FEBS Letters, 401 (2-3). pp. 213-217. ISSN 0014-5793

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Abstract

We have isolated cDNA clones corresponding to a new member of the murine tissue inhibitor of metalloproteinase (TIMP) family, designated Timp-4. The nucleotide sequence predicts a protein of 22,609 Da that contains the characteristic 12 cysteine TIMP signature. TIMP-4 is more closely related to TIMP-2 and TIMP-3 than to TIMP-1 (48%, 45% and 38% identity, respectively). Analysis of Timp-4 mRNA expression in adult mouse tissues indicated a 1.2 kb transcript in brain, heart, ovary and skeletal muscle. This pattern of expression distinguishes Timp-4 from other Timps, suggesting that the TIMP-4 protein may be an important tissue-specific regulator of extracellular matrix remodelling.

Item Type: Article
Uncontrolled Keywords: amino acid sequence,animals,base sequence,cloning, molecular,dna, complementary,enzyme inhibitors,male,metalloendopeptidases,mice,molecular sequence data,proteins,rna,sequence homology, amino acid,tissue inhibitor of metalloproteinases
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 25 Mar 2015 13:56
Last Modified: 23 Sep 2022 01:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/52962
DOI: 10.1016/S0014-5793(96)01474-3

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