Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues

Leco, Kevin J., Apte, Suneel S., Taniguchi, Gary T., Hawkes, Susan P., Khokha, Rama, Schultz, Gilbert A. and Edwards, Dylan R. (1997) Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues. FEBS Letters, 401 (2-3). pp. 213-217. ISSN 0014-5793

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Abstract

We have isolated cDNA clones corresponding to a new member of the murine tissue inhibitor of metalloproteinase (TIMP) family, designated Timp-4. The nucleotide sequence predicts a protein of 22,609 Da that contains the characteristic 12 cysteine TIMP signature. TIMP-4 is more closely related to TIMP-2 and TIMP-3 than to TIMP-1 (48%, 45% and 38% identity, respectively). Analysis of Timp-4 mRNA expression in adult mouse tissues indicated a 1.2 kb transcript in brain, heart, ovary and skeletal muscle. This pattern of expression distinguishes Timp-4 from other Timps, suggesting that the TIMP-4 protein may be an important tissue-specific regulator of extracellular matrix remodelling.

Item Type:	Article
Uncontrolled Keywords:	amino acid sequence,animals,base sequence,cloning, molecular,dna, complementary,enzyme inhibitors,male,metalloendopeptidases,mice,molecular sequence data,proteins,rna,sequence homology, amino acid,tissue inhibitor of metalloproteinases
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Cells and Tissues Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User:	Pure Connector
Date Deposited:	25 Mar 2015 13:56
Last Modified:	06 Feb 2025 05:36
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52962
DOI:	10.1016/S0014-5793(96)01474-3

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