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Clark, Arthur W., Krekoski, Craig A., Bou, Shao-Sun, Chapman, Kevin R. and Edwards, Dylan R. 
ORCID: https://orcid.org/0000-0002-3292-2064
(1997)
Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia.
Neuroscience Letters, 238 (1-2).
pp. 53-6.
ISSN 0304-3940
Abstract
Matrix metalloproteinases (MMPs) are involved in remodelling extracellular matrix. Gelatinase B (MMP-9) is an inducible 92 kDa MMP expressed by neutrophils, microglia, and endothelial cells. Gelatinase A (MMP-2) is a 72 kDa MMP, constitutively expressed in brain. Elevated MMP activity has been linked to various pathologic conditions, and the therapeutic benefit of MMP inhibitors is under study in a few experimental models. Using gelatin zymography, we have compared activities of these MMPs in infarcted and matched non-infarcted cerebral tissue from eight subjects dying at intervals of less than 2 h to several years after a stroke. Gelatinase B activity was markedly elevated in the infarcted tissue at two days post-infarction, and remained elevated in cases dying months after the event. Increases in gelatinase A activity were subtle at 2-5 days; they were marked and significant in cases dying at 4 months and later. The findings indicate distinct temporal profiles of post-ischemic gelatinase activity in human brain, with earlier but equally persistent elevation in gelatinase B when compared to gelatinase A.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | aged,aged, 80 and over,brain ischemia,collagenases,female,gelatinases,humans,male,matrix metalloproteinase 2,matrix metalloproteinase 9,metalloendopeptidases,middle aged,time factors |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Cells and Tissues Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies |
| Depositing User: | Pure Connector |
| Date Deposited: | 25 Mar 2015 13:52 |
| Last Modified: | 19 Apr 2023 00:36 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/52960 |
| DOI: | 10.1016/S0304-3940(97)00859-8 |
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