Metabolic manipulation in chronic heart failure: Study protocol for a randomised controlled trial

Beadle, Roger M., Williams, Lynne K., Abozguia, Khaild, Patel, Kiran, Leon, Francisco Leyva, Yousef, Zaheer, Wagenmakers, Anton and Frenneaux, Michael P. (2011) Metabolic manipulation in chronic heart failure: Study protocol for a randomised controlled trial. Trials, 12. ISSN 1745-6215

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Abstract

Heart failure is a major cause of morbidity and mortality in society. Current medical therapy centres on neurohormonal modulation with angiotensin converting enzyme inhibitors and β-blockers. There is growing evidence for the use of metabolic manipulating agents as adjunctive therapy in patients with heart failure. We aim to determine the effect of perhexiline on cardiac energetics and alterations in substrate utilisation in patients with non-ischaemic dilated cardiomyopathy.

Item Type:	Article
Additional Information:	Acknowledgements: This is an investigator-led study kindly funded by the British Heart Foundation (PG/06/105).
Uncontrolled Keywords:	adenosine triphosphate,cardiac catheterization,cardiomyopathy, dilated,cardiovascular agents,double-blind method,drug monitoring,echocardiography, doppler,energy metabolism,great britain,heart failure,humans,magnetic resonance imaging,magnetic resonance spectroscopy,myocardium,perhexiline,phosphocreatine,placebo effect,prospective studies,recovery of function,research design,stroke volume,time factors,treatment outcome,ventricular function, left
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	23 Mar 2015 13:16
Last Modified:	07 Oct 2024 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52809
DOI:	10.1186/1745-6215-12-140

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