Effects of bradykinin on venous capacitance in health and treated chronic heart failure

Gunaruwan, Prasad, Maher, Abdul, Williams, Lynne, Sharman, James, Schmitt, Matthias, Campbell, Ross and Frenneaux, Michael (2009) Effects of bradykinin on venous capacitance in health and treated chronic heart failure. Clinical Science, 116 (5). pp. 443-50. ISSN 1470-8736

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Abstract

In the present study, we investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow in healthy volunteers (n=20) and in chronic heart failure patients treated with ACEIs [ACE (angiotensin-converting enzyme) inhibitors] (n=16) and ARBs (angiotensin receptor blockers) (n=14). We used radionuclide plethysmography to examine the effects of bradykinin and of the bradykinin antagonists B9340 [B1 (type 1)/B2 (type 2) receptor antagonist] and HOE140 (B2 antagonist). Bradykinin infusion increased unstressed forearm vascular volume in a similar dose-dependent manner in healthy volunteers and ARB-treated CHF patients (healthy volunteers maximum 12.3+/-2.1%, P

Item Type:	Article
Uncontrolled Keywords:	aged,aged, 80 and over,angiotensin ii type 1 receptor blockers,angiotensin-converting enzyme inhibitors,bradykinin,bradykinin receptor antagonists,dose-response relationship, drug,female,forearm,heart failure,humans,male,middle aged,receptors, bradykinin,regional blood flow,vascular resistance,vasodilator agents
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	23 Mar 2015 13:10
Last Modified:	23 Apr 2023 01:03
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52801
DOI:	10.1042/CS20080096

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