Protocol: Does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)

Siddiqi, Nishat, Bruce, Margaret, Neil, Christopher J., Jagpal, Baljit, Maclennon, Graeme, Cotton, Seonaidh C., Papadopoulo, Sofia A., Bunce, Nicholas, Lim, Pitt, Schwarz, Konstantin, Singh, Satnam, Hildick-Smith, David, Horowitz, John D., Madhani, Melanie, Boon, Nicholas, Kaski, Juan-Carlos, Dawson, Dana and Frenneaux, Michael P. (2013) Protocol: Does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI). Journal of Translational Medicine, 11. ISSN 1479-5876

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Abstract

Whilst advances in reperfusion therapies have reduced early mortality from acute myocardial infarction, heart failure remains a common complication, and may develop very early or long after the acute event. Reperfusion itself leads to further tissue damage, a process described as ischaemia-reperfusion-injury (IRI), which contributes up to 50% of the final infarct size. In experimental models nitrite administration potently protects against IRI in several organs, including the heart. In the current study we investigate whether intravenous sodium nitrite administration immediately prior to percutaneous coronary intervention (PCI) in patients with acute ST segment elevation myocardial infarction will reduce myocardial infarct size. This is a phase II, randomised, placebo-controlled, double-blinded and multicentre trial.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,aged,cardiotonic agents,double-blind method,female,great britain,humans,magnetic resonance imaging,male,middle aged,myocardial infarction,nitric oxide,percutaneous coronary intervention,reperfusion injury,sodium nitrite,young adult
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	13 Mar 2015 16:30
Last Modified:	23 Apr 2023 01:01
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52641
DOI:	10.1186/1479-5876-11-116

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