Physical stabilization of low-molecular-weight amorphous drugs in the solid state: A material science approach

Qi, Sheng ORCID: https://orcid.org/0000-0003-1872-9572, Yang, Ziyi, McAuley, William and Tipduangta, Pratchaya (2014) Physical stabilization of low-molecular-weight amorphous drugs in the solid state: A material science approach. Therapeutic Delivery, 5 (7). pp. 817-841. ISSN 2041-5990

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Abstract

Use of the amorphous state is considered to be one of the most effective approaches for improving the dissolution and subsequent oral bioavailability of poorly water-soluble drugs. However as the amorphous state has much higher physical instability in comparison with its crystalline counterpart, stabilization of amorphous drugs in a solid-dosage form presents a major challenge to formulators. The currently used approaches for stabilizing amorphous drug are discussed in this article with respect to their preparation, mechanism of stabilization and limitations. In order to realize the potential of amorphous formulations, significant efforts are required to enable the prediction of formulation performance. This will facilitate the development of computational tools that can inform a rapid and rational formulation development process for amorphous drugs.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Pure Connector
Date Deposited:	09 Mar 2015 07:35
Last Modified:	07 Oct 2024 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52549
DOI:	10.4155/tde.14.39

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