Modulation of the natriuretic peptide system in heart failure: From bench to bedside?

Schmitt, Matthias, Cockcroft, John R and Frenneaux, Michael P (2003) Modulation of the natriuretic peptide system in heart failure: From bench to bedside? Clinical Science, 105 (2). pp. 141-60. ISSN 0143-5221

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Abstract

Since the discovery of atrial natriuretic peptide, the unravelling of the natriuretic peptide system has been a story of scientific success. However, bridging the gap between bench and bedside has proved difficult, and as yet has not provided any major clinical progress. In this review we will first give a detailed outline of the key elements constituting the natriuretic peptide system. Secondly, we will briefly explain the underlying rationale, basic concepts and evidence behind currently pursued strategies to potentiate the natriuretic peptide system. Thirdly, we will highlight some of the problems that have so far hindered successful translation of these theoretically viable treatment options into tangible clinical progress.

Item Type:	Article
Uncontrolled Keywords:	animals,atrial natriuretic factor,cardiotonic agents,heart failure,humans,mice,natriuretic peptide, brain,natriuretic peptide, c-type,peptide hormones
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	09 Mar 2015 07:30
Last Modified:	07 Oct 2024 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52455
DOI:	10.1042/CS20030044

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