Addition of candesartan to angiotensin converting enzyme inhibitor therapy in patients with chronic heart failure does not reduce levels of oxidative stress

Ellis, Gethin R., Nightingale, Angus K., Blackman, Daniel J., Anderson, Richard A., Mumford, Catherine, Timmins, Graham, Lang, Derek, Jackson, Simon K., Penney, Michael D., Lewis, Malcolm J., Frenneaux, Michael P. and Morris-Thurgood, Jayne (2002) Addition of candesartan to angiotensin converting enzyme inhibitor therapy in patients with chronic heart failure does not reduce levels of oxidative stress. European Journal of Heart Failure, 4 (2). pp. 193-199. ISSN 1388-9842

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Abstract

Angiotensin II exerts a number of harmful effects in patients with chronic heart failure (CHF) and, through an increase in oxidative stress, is thought to be critical in the development of endothelial dysfunction. Angiotensin II may be elevated in CHF despite treatment with angiotensin converting enzyme (ACE) inhibitors, producing a rationale for adjunctive angiotensin receptor blockade. We investigated whether the addition of angiotensin antagonism to ACE inhibition would reduce oxidative stress and improve endothelial function and exercise tolerance in patients with chronic heart failure.

Item Type:	Article
Uncontrolled Keywords:	adult,aged,angiotensin-converting enzyme inhibitors,antihypertensive agents,benzimidazoles,blood pressure,brachial artery,chronic disease,drug therapy, combination,endothelium, vascular,exercise tolerance,female,follow-up studies,heart failure,heart rate,humans,lipid peroxidation,male,middle aged,natriuretic peptide, brain,oxidative stress,stroke volume,tetrazoles,time factors,treatment outcome
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	09 Mar 2015 07:30
Last Modified:	15 Aug 2023 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52445
DOI:	10.1016/S1388-9842(02)00002-8

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