The effect of perhexiline on myocardial protection during coronary artery surgery:a two-centre, randomized, double-blind, placebo-controlled trial

Drury, Nigel E, Howell, Neil J, Calvert, Melanie J, Weber, Ralf J M, Senanayake, Eshan L, Lewis, Michael E, Hyde, Jonathan A J, Green, David H, Mascaro, Jorge G, Wilson, Ian C, Graham, Timothy R, Rooney, Stephen J, Viant, Mark R, Freemantle, Nick, Frenneaux, Michael P, Pagano, Domenico and , investigators (2015) The effect of perhexiline on myocardial protection during coronary artery surgery:a two-centre, randomized, double-blind, placebo-controlled trial. European Journal of Cardio-Thoracic Surgery, 47 (3). pp. 464-472. ISSN 1873-734X

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Abstract

Perhexiline is thought to modulate metabolism by inhibiting mitochondrial carnitine palmitoyltransferase-1, reducing fatty acid uptake and increasing carbohydrate utilization. This study assessed whether preoperative perhexiline improves markers of myocardial protection in patients undergoing coronary artery bypass graft surgery and analysed its effect on the myocardial metabolome.

Item Type: Article
Additional Information: © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 25 Feb 2015 06:16
Last Modified: 21 Apr 2020 23:53
URI: https://ueaeprints.uea.ac.uk/id/eprint/52410
DOI: 10.1093/ejcts/ezu238

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