Relationship between plasma, atrial and ventricular perhexiline concentrations in humans:insights into factors affecting myocardial uptake

Drury, Nigel E, Licari, Giovanni, Chong, Cher-Rin, Howell, Neil J, Frenneaux, Michael P, Horowitz, John D, Pagano, Domenico and Sallustio, Benedetta C (2014) Relationship between plasma, atrial and ventricular perhexiline concentrations in humans:insights into factors affecting myocardial uptake. British Journal of Clinical Pharmacology, 77 (5). pp. 789-95. ISSN 0306-5251

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Abstract

Little is known regarding the steady-state uptake of drugs into the human myocardium. Perhexiline is a prophylactic anti-anginal drug which is increasingly also used in the treatment of heart failure and hypertrophic cardiomyopathy. We explored the relationship between plasma perhexiline concentrations and its uptake into the myocardium.

Item Type:	Article
Additional Information:	© 2013 The British Pharmacological Society.
Uncontrolled Keywords:	age factors,aged,biopsy,double-blind method,humans,middle aged,myocardium,perhexiline,prospective studies
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	09 Mar 2015 07:28
Last Modified:	15 Oct 2025 10:33
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52409
DOI:	10.1111/bcp.12254

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