Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics

Lele, S S, Durrant, S T, Atherton, J J, Moore, T D, Thomson, H L, Khafagi, F A and Frenneaux, M P (1996) Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics. Bone Marrow Transplantation, 17 (6). pp. 1113-1118. ISSN 0268-3369

Full text not available from this repository.

Abstract

We evaluated the role of rest and exercise left ventricular diastolic filling parameters as a marker of cardiotoxicity in 25 consecutive patients 1 year following BMT. Ten age- and sex-matched subjects served as controls. Patients were evaluated in toto and in three sub-groups according to chemotherapy. Left ventricular ejection fraction (EF), peak filling rate (PFR) and time to peak filling (TTPF) were assessed at rest and at peak exercise. EF and PFR were similar at rest and at peak exercise in patients and controls. TTPF was significantly prolonged at rest in patients compared to controls (200 +/- 65 vs 131 +/- 26 ms, P = 0.003) and at peak exercise was markedly longer in patients (142 +/- 40 vs 54 +/- 19 ms, P

Item Type:	Article
Uncontrolled Keywords:	adult,bone marrow transplantation,cyclophosphamide,diastole,exercise test,female,humans,male,middle aged,transplantation conditioning,ventricular function, left
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	27 Feb 2015 13:22
Last Modified:	22 Apr 2023 22:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52380
DOI:

Actions (login required)

View Item