Intravenous sodium nitrite in acute ST-elevation myocardial infarction: A randomized controlled trial (NIAMI)

Siddiqi, Nishat, Neil, Christopher, Bruce, Margaret, MacLennan, Graeme, Cotton, Seonaidh, Papadopoulou, Sofia, Feelisch, Martin, Bunce, Nicholas, Lim, Pitt O., Hildick-Smith, David, Horowitz, John, Madhani, Melanie, Boon, Nicholas, Dawson, Dana, Kaski, Juan Carlos, Frenneaux, Michael, Siddiqi, Nishat, Neil, Christopher, Bruce, Margaret, MacLennan, Graeme, Cotton, Seonaidh, Dawson, Dana, Singh, Satnam, Schwarz, Konstantin, Jagpal, Baljit, Metcalfe, Malcolm, Stewart, Andrew, Hannah, Andrew, Awsan, Noman, Broadhurst, Paul, Hogg, Duncan, Garg, Deepak, Slattery, Elaine, Davidson, Tracey, McDonald, Alison, McPherson, Gladys, Kaski, Juan-Carlo, Lim, Pitt O., Brown, Sue, Papadopoulou, Sofia A., Gonzalvez, Fatima, Roy, David, Firoozi, Sami, Bogle, Richard, Roberts, Elved, Rhodes, Jonathan, Hildick-Smith, David, de Belder, Adam, Cooter, Nina, Bennett, Lorraine, Horowitz, John, Rajendran, Sharmalar, Dautov, Rustem, Black, Marilyn, Jansen, Else, Boon, Nicholas, Struthers, Allan, Toff, William, Dargie, Henry, Lang, Chim and Nightingale, Peter (2014) Intravenous sodium nitrite in acute ST-elevation myocardial infarction: A randomized controlled trial (NIAMI). European Heart Journal, 35 (19). pp. 1255-1262. ISSN 0195-668X

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Abstract

Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).

Item Type:	Article
Uncontrolled Keywords:	acute myocardial infarction,ischaemia-reperfusion injury,cardioprotection,nitrite
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Related URLs:	http://dx.doi.org/10.1093/eurheartj/ehu0...
Depositing User:	Pure Connector
Date Deposited:	25 Feb 2015 06:14
Last Modified:	07 Oct 2024 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52291
DOI:	10.1093/eurheartj/ehu096

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