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Lamond, Nathan W D, Skedgel, Chris 
ORCID: https://orcid.org/0000-0003-4989-8846 and Younis, Tallal
(2013)
Is the 21-gene recurrence score a cost-effective assay in endocrine-sensitive node-negative breast cancer?
Expert Review of Pharmacoeconomics & Outcomes Research, 13 (2).
pp. 243-50.
ISSN 1473-7167
Abstract
The 21-gene recurrence score (RS) is a gene expression profile assay currently endorsed for use in patients with endocrine-sensitive node-negative breast cancers. The RS has been shown to augment current 'prognostic' and 'predictive' assessments of relapse risk and chemotherapy benefits, respectively, and lead to significant change in oncologists' recommendations for adjuvant chemotherapy, with an overall reduction in chemotherapy utilization. The RS (Oncotype DX) is marketed by Genomic Health Inc. (CA, USA) and currently retails for approximately US$4290 per patient. Like all novel tests/therapies, however, these upfront costs should be examined in the context of all its clinical benefits through cost-effectiveness or cost-utility evaluations. This review highlights the clinical evidence supporting RS testing for patients with endocrine-sensitive node-negative breast cancers, and examines all published economic evaluations that examined its 'value for money' in this setting.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 21-gene recurrence score,breast cancer,cost-effectiveness,cost-utility,gene expression,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Health Economics Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) |
| Depositing User: | Pure Connector |
| Date Deposited: | 03 Feb 2015 13:06 |
| Last Modified: | 21 Oct 2022 00:29 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/51929 |
| DOI: | 10.1586/erp.13.4 |
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