Risk of breast cancer after onset of type 2 diabetes: Evidence of detection bias in postmenopausal women

Bowker, Samantha L., Richardson, Kathryn ORCID: https://orcid.org/0000-0002-0741-8413, Marra, Carlo A. and Johnson, Jeffrey A. (2011) Risk of breast cancer after onset of type 2 diabetes: Evidence of detection bias in postmenopausal women. Diabetes Care, 34 (12). pp. 2542-2544. ISSN 0149-5992

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Abstract

OBJECTIVE: To examine the risk of breast cancer in pre- and postmenopausal women with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: This was a population-based retrospective cohort study. Cox regression, stratified by pre- (<55 years) and postmenopausal (≥55 years) status, was used to estimate hazard ratios (HRs) for breast cancer, during earlier (0–3 months) and later (3 months to 10 years) time windows after diabetes index date. RESULTS: Compared with women without T2D, HRs for breast cancer were 0.95 (95% CI 0.48–1.86; P = 0.88) and 1.31 (0.92–1.86; P = 0.14) in pre- and postmenopausal women with T2D, respectively, in the early time window, and 0.92 (0.75–1.13; P = 0.45) and 1.00 (0.90–1.11; P = 0.93) in pre- and postmenopausal women with T2D, respectively, in the later time window. CONCLUSIONS: We observed a trend toward an increased risk of breast cancer in postmenopausal women with T2D, but only in the time period immediately after diabetes index date.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Health Promotion Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User:	Pure Connector
Date Deposited:	05 Jan 2015 15:06
Last Modified:	20 Jun 2023 09:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/51646
DOI:	10.2337/dc11-1199

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