Development of a LC-MS/MS method for the measurement of total fractionated urine metadrenalines and determination of a healthy population reference range

Banks, A, Dutton, John, Phillipson, K and Davison, AS (2014) Development of a LC-MS/MS method for the measurement of total fractionated urine metadrenalines and determination of a healthy population reference range. In: EuroLabFocus, 2014-10-07 - 2014-10-10.

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Abstract

Phaeochromocytoma (PCC) and paraganglioma (PGL) are rare neuroendocrine tumours that arise from chromaffin tissue, typically in the adrenal medulla. They are characterised by the secretion of catecholamines and their methylated metabolites (metadrenaline, normetadrenaline and 3-methoxytyramine). PCC/PGL pose a diagnostic dilemma to clinicians as they often present with non-specific symptoms (e.g. hypertension, sweating), or are found incidentally on imaging. Measurement of plasma or urine metadrenalines are recommended for the investigation of PCC as they offer superior diagnostic performance characteristics compared to catecholamines.

Item Type:	Conference or Workshop Item (Poster)
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Pure Connector
Date Deposited:	21 Nov 2014 12:30
Last Modified:	10 Aug 2021 23:50
URI:	https://ueaeprints.uea.ac.uk/id/eprint/51132
DOI:

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