How fatty acids and common genetic variants together affect the inflammation of adipose tissue

Slim, Kenna and Minihane, Anne-Marie ORCID: https://orcid.org/0000-0001-9042-4226 (2014) How fatty acids and common genetic variants together affect the inflammation of adipose tissue. Current Cardiovascular Risk Reports, 8. ISSN 1932-9563

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Abstract

Adipose tissue (AT) expansion is associated with the recruitment of additional macrophages and a proinflammatory adipokine profile. The inflammatory status of AT is an important determinant of the metabolic and pathologic consequences of obesity and the risk of comorbidities such as type 2 diabetes and nonalcoholic fatty liver disease. It has more recently also been linked to dementia and accelerated brain ageing. Given that fatty acids regulate cellular inflammation through their impact on the eicosanoid profile and on adipokine expression, it is likely that habitual fatty acid intake and AT fatty acid status, is important in regulating AT inflammation. Furthermore, although as yet poorly researched and understood, common variants in inflammatory genes and in their receptors and regulators may influence their production and overall AT function. In an era where population weight reduction strategies have had limited success, an understanding of AT inflammation and its regulation by dietary strategies aimed at resulting in a ‘metabolically healthy obese phenotype,’ is of wide public health relevance.

Item Type:	Article
Uncontrolled Keywords:	obesity,bmi,waist,hypertrophy,genotype,gwas,insulin sensitivity,inflammation,macrophages,cytokines,adipokines,adiponectin,tnfα,il-6,apolipoprotein e,n-3 pufa,saturated fatty acids,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Pure Connector
Date Deposited:	31 Oct 2014 12:56
Last Modified:	19 Oct 2023 01:22
URI:	https://ueaeprints.uea.ac.uk/id/eprint/50523
DOI:	10.1007/s12170-014-0411-8

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