Fecal incontinence in systemic sclerosis is secondary to neuropathy

Thoua, Nora M, Abdel-Halim, Mostafa, Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843, Denton, Chris P and Emmanuel, Anton V (2012) Fecal incontinence in systemic sclerosis is secondary to neuropathy. The American Journal of Gastroenterology, 107 (4). pp. 597-603. ISSN 0002-9270

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Abstract

Systemic sclerosis (SSc) is a chronic multi-system autoimmune disorder with gastrointestinal tract (GIT) involvement in up to 90% of patients and anorectal involvement occurs in up to 50% of patients. The pathogenesis of gastrointestinal abnormalities may be both myogenic and neurogenic. We aimed to identify which anorectal physiological abnormalities correlate with clinical symptoms and thus understand the pathophysiology of anorectal involvement in SSc.

Item Type:	Article
Uncontrolled Keywords:	aged,anal canal,analysis of variance,case-control studies,chi-square distribution,fecal incontinence,female,humans,male,manometry,middle aged,pressure,rectum,reflex, abdominal,regional blood flow,scleroderma, systemic,sensory thresholds,statistics, nonparametric
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:58
Last Modified:	21 Oct 2022 00:03
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49836
DOI:	10.1038/ajg.2011.399

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