Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Parkes, Miles, Barrett, Jeffrey C, Prescott, Natalie J, Tremelling, Mark, Anderson, Carl A, Fisher, Sheila A, Roberts, Roland G, Nimmo, Elaine R, Cummings, Fraser R, Soars, Dianne, Drummond, Hazel, Lees, Charlie W, Khawaja, Saud A, Bagnall, Richard, Burke, Denis A, Todhunter, Catherine E, Ahmad, Tariq, Onnie, Clive M, McArdle, Wendy, Strachan, David, Bethel, Graeme, Bryan, Claire, Lewis, Cathryn M, Deloukas, Panos, Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843, Sanderson, Jeremy, Jewell, Derek P, Satsangi, Jack, Mansfield, John C, Cardon, Lon and Mathew, Christopher G and Wellcome Trust Case Control Consortium (2007) Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nature Genetics, 39 (7). pp. 830-2. ISSN 1061-4036

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Abstract

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

Item Type:	Article
Uncontrolled Keywords:	animals,autophagy,case-control studies,crohn disease,gtp-binding proteins,genetic predisposition to disease,genetic variation,humans,mice,polymorphism, single nucleotide,sequence analysis, dna
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:52
Last Modified:	03 Nov 2022 15:37
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49678
DOI:	10.1038/ng2061

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