A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5

Prescott, Natalie J, Fisher, Sheila A, Franke, Andre, Hampe, Jochen, Onnie, Clive M, Soars, Dianne, Bagnall, Richard, Mirza, Muddassar M, Sanderson, Jeremy, Forbes, Alastair, Mansfield, John C, Lewis, Cathryn M, Schreiber, Stefan and Mathew, Christopher G (2007) A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology, 132 (5). pp. 1665-71. ISSN 0016-5085

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Abstract

A genome-wide association scan of nonsynonymous DNA polymorphisms identified association of a threonine-to-alanine substitution (T300A) in the autophagy-related 16-like gene ATG16L1 with Crohn's disease. We investigated this association in independent U.K. cohorts of Crohn's disease and ulcerative colitis.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,aged,autophagy,carrier proteins,child,child, preschool,chromosomes, human, pair 5,cohort studies,colitis, ulcerative,crohn disease,epistasis, genetic,female,genetic predisposition to disease,genotype,great britain,humans,ileitis,male,middle aged,models, genetic,nod2 signaling adaptor protein,polymorphism, single nucleotide,risk factors,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:54
Last Modified:	06 Feb 2025 05:07
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49675
DOI:	10.1053/j.gastro.2007.03.034

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