Prescott, Natalie J, Fisher, Sheila A, Franke, Andre, Hampe, Jochen, Onnie, Clive M, Soars, Dianne, Bagnall, Richard, Mirza, Muddassar M, Sanderson, Jeremy, Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843, Mansfield, John C, Lewis, Cathryn M, Schreiber, Stefan and Mathew, Christopher G (2007) A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology, 132 (5). pp. 1665-71. ISSN 0016-5085
Full text not available from this repository. (Request a copy)Abstract
A genome-wide association scan of nonsynonymous DNA polymorphisms identified association of a threonine-to-alanine substitution (T300A) in the autophagy-related 16-like gene ATG16L1 with Crohn's disease. We investigated this association in independent U.K. cohorts of Crohn's disease and ulcerative colitis.
Item Type: | Article |
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Uncontrolled Keywords: | adolescent,adult,aged,autophagy,carrier proteins,child,child, preschool,chromosomes, human, pair 5,cohort studies,colitis, ulcerative,crohn disease,epistasis, genetic,female,genetic predisposition to disease,genotype,great britain,humans,ileitis,male,middle aged,models, genetic,nod2 signaling adaptor protein,polymorphism, single nucleotide,risk factors,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine |
Depositing User: | Pure Connector |
Date Deposited: | 06 Aug 2014 10:54 |
Last Modified: | 21 Oct 2022 00:00 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/49675 |
DOI: | 10.1053/j.gastro.2007.03.034 |
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