Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor

Harbord, M W N, Marks, D J B, Forbes, A ORCID: https://orcid.org/0000-0001-7416-9843, Bloom, S L, Day, R M and Segal, A W (2006) Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor. Alimentary Pharmacology and Therapeutics, 24 (4). pp. 651-660. ISSN 0269-2813

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Abstract

Defective neutrophil recruitment has been described as a primary pathogenic abnormality in Crohn's disease. Cantharidin-induced blisters provide a novel investigative tool to assess cellular influx and inflammatory mediator production during acute inflammation and allows the effects of therapy on these parameters to be measured.

Item Type:	Article
Uncontrolled Keywords:	adult,aged,chemokines,chemotaxis, leukocyte,crohn disease,female,granulocyte colony-stimulating factor,humans,male,middle aged,neutrophils
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:46
Last Modified:	21 Oct 2022 00:00
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49666
DOI:	10.1111/j.1365-2036.2006.03016.x

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