Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease?

Polymeros, Dimitrios, Bogdanos, Dimitrios P, Day, Richard, Arioli, Dimitryi, Vergani, Diego and Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843 (2006) Does cross-reactivity between mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease? Gastroenterology, 131 (1). pp. 85-96. ISSN 0016-5085

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Abstract

Most Crohn's disease (CD) patients show seroreactivity against Mycobacterium avium paratuberculosis (MAP), suggesting a pathogenic role for this organism. Our aim was to seek amino acid similarities between MAP and intestinal proteins that, through molecular mimicry, could serve as targets for cross-reactive immunity in CD.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,aged,aged, 80 and over,antibody affinity,autoantigens,crohn disease,enzyme-linked immunosorbent assay,female,glutathione peroxidase,humans,male,middle aged,mycobacterium avium subsp. paratuberculosis,paratuberculosis,prognosis,severity of illness index,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:54
Last Modified:	21 Oct 2022 00:00
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49661
DOI:	10.1053/j.gastro.2006.04.021

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