Crohn's disease:the cold chain hypothesis

Forbes, Alastair ORCID: and Kalantzis, Tommy (2006) Crohn's disease:the cold chain hypothesis. International Journal of Colorectal Disease, 21 (5). pp. 399-401. ISSN 0179-1958

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A recent published hypothesis proposed that Crohn's disease was provoked by infantile exposure to micro-organisms that can survive refrigerator temperature. A case-control study was accordingly devised. The mean age at first fridge was 5.6 years amongst 88 patients with Crohn's disease, 5.5 years in 88 patients with ulcerative colitis (UC) and 7.6 years in 88 controls, but a majority of individuals had always been exposed to refrigerated food. Differences were more striking in subjects aged above the median (10.3, 10.9 and 15.0 years for Crohn's disease, UC and controls, respectively). This support for the hypothesis reached statistical significance for those with Crohn's disease compared to the controls (p=0.045).

Item Type: Article
Uncontrolled Keywords: adolescent,adult,bacteria,case-control studies,child,child, preschool,crohn disease,female,food microbiology,humans,male,refrigeration
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 10:44
Last Modified: 20 Oct 2022 23:59
DOI: 10.1007/s00384-005-0003-7

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