Human lymphocyte stimulation with pouchitis flora is greater than with flora from a healthy pouch but is suppressed by metronidazole

Bell, A J G, Nicholls, R J, Forbes, A ORCID: https://orcid.org/0000-0001-7416-9843, Ellis, H J and Ciclitira, P J (2004) Human lymphocyte stimulation with pouchitis flora is greater than with flora from a healthy pouch but is suppressed by metronidazole. Gut, 53 (12). pp. 1801-1805. ISSN 0017-5749

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Abstract

The gut flora may play an important role in the pathogenesis of inflammatory bowel disease. An ileal reservoir or pouch can be created to replace the excised rectum after proctocolectomy. In patients with ulcerative colitis this is subject to inflammation and termed pouchitis. Using bacteria from patients the authors sought evidence for the presence rather than the identity of a pathogenic species in pouchitis, and for its absence in healthy pouches by the differential effect on lymphocyte proliferation.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,aged,anti-bacterial agents,bacteria,cell division,cells, cultured,colonic pouches,female,humans,lymphocyte activation,male,metronidazole,middle aged,pouchitis,sonication,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:36
Last Modified:	20 Oct 2022 23:59
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49627
DOI:	10.1136/gut.2003.026807

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