Altered expression of the lymphocyte activation markers CD30 and CD27 in patients with pouchitis

Thomas, P D, Forbes, A ORCID: https://orcid.org/0000-0001-7416-9843, Nicholls, R J and Ciclitira, P J (2001) Altered expression of the lymphocyte activation markers CD30 and CD27 in patients with pouchitis. Scandinavian Journal of Gastroenterology, 36 (3). pp. 258-264. ISSN 0036-5521

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Abstract

The mechanism underlying the development of ileal pouch inflammation in ulcerative colitis patients (pouchitis) after restorative proctocolectomy is unclear. Persistent systemic T cell activation or expansion of specific memory cell populations could predispose certain patients to develop local inflammation within the neo-rectum. Therefore, the aim was to study the expression of the lymphocyte activation markers CD27, CD30, CD25 and CD69 on the CD45RO+ memory cell subset of isolated peripheral blood mononuclear cells (PBMC), soluble CD30 levels and mucosal CD30 expression in patients with pouchitis and in controls.

Item Type:	Article
Uncontrolled Keywords:	adult,antigens, cd27,antigens, cd30,biological markers,biopsy, needle,colitis, ulcerative,female,flow cytometry,humans,immunohistochemistry,male,middle aged,monocytes,photomicrography,pouchitis,probability,proctocolectomy, restorative,reference values,sensitivity and specificity,statistics, nonparametric
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:58
Last Modified:	20 Oct 2022 23:58
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49573
DOI:	10.1080/00365520120210

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