Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

Merson, S, Yang, Z H, Brewer, D, Olmos, D, Eichholz, A, McCarthy, F, Fisher, G, Kovacs, G, Berney, D M, Foster, C S, Møller, H, Scardino, P, Cuzick, J, Cooper, C S, Clark, Jeremy and , Transatlantic Prostate Group (2014) Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer. British Journal of Cancer, 110 (6). pp. 1655-62. ISSN 0007-0920

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Abstract

Androgen receptor (AR)-gene amplification, found in 20-30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment failure. Here we investigate AR-gene amplification in cancers before hormone deprivation therapy.

Item Type: Article
Faculty \ School: Faculty of Science
Faculty of Science > School of Biological Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 09 Jul 2014 12:26
Last Modified: 24 Jul 2019 20:06
URI: https://ueaeprints.uea.ac.uk/id/eprint/49306
DOI: 10.1038/bjc.2014.13

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