Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

Merson, S, Yang, Z H, Brewer, D ORCID: https://orcid.org/0000-0003-4753-9794, Olmos, D, Eichholz, A, McCarthy, F, Fisher, G, Kovacs, G, Berney, D M, Foster, C S, Møller, H, Scardino, P, Cuzick, J, Cooper, C S ORCID: https://orcid.org/0000-0003-2013-8042 and Clark, Jeremy and Transatlantic Prostate Group (2014) Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer. British Journal of Cancer, 110 (6). pp. 1655-1662. ISSN 0007-0920

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Abstract

Androgen receptor (AR)-gene amplification, found in 20-30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment failure. Here we investigate AR-gene amplification in cancers before hormone deprivation therapy.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science Faculty of Science > School of Biological Sciences Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	09 Jul 2014 12:26
Last Modified:	19 Oct 2023 01:20
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49306
DOI:	10.1038/bjc.2014.13

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