The effect of riboflavin deficiency in rats on the absorption and distribution of iron

Powers, H J, Wright, A J and Fairweather-Tait, S J (1988) The effect of riboflavin deficiency in rats on the absorption and distribution of iron. British Journal of Nutrition, 59 (3). pp. 381-387. ISSN 0007-1145

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Abstract

1. Riboflavin may play a part in the transport of iron across the gastrointestinal mucosa. Fe absorption was measured in the rat by monitoring whole-body retention of a dose of 59Fe using a small-animal gamma-counter. 2. Female Norwegian Hooded rats were fed on a diet deficient in riboflavin (B2-) from 5 weeks of age. Control animals, fed on a complete diet (B2+), were weight-matched to rats fed on the B2- diet. After 7 weeks all rats were fed on a test meal extrinsically labelled with 59Fe and whole-body radioactivity measured for 15 d. 3. Riboflavin deficiency was associated with a reduction in the percentage of the dose absorbed and an increase in the rate of loss of Fe post absorption. 4. A smaller percentage of the absorbed dose was present in the livers of the riboflavin-deficient animals.

Item Type: Article
Uncontrolled Keywords: animals,biological transport,female,intestinal absorption,intestinal mucosa,iron,organ size,rats,riboflavin deficiency,tissue distribution
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Social Sciences > Norwich Business School
Depositing User: Pure Connector
Date Deposited: 05 Aug 2014 12:56
Last Modified: 28 Oct 2019 13:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/49253
DOI:

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