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Harvey, Linda J, Dainty, Jack R 
ORCID: https://orcid.org/0000-0002-0056-1233, Hollands, Wendy J, Bull, Victoria J, Hoogewerff, Jurian A, Foxall, Robert J, McAnena, Liadhan, Strain, J J and Fairweather-Tait, Susan J ORCID: https://orcid.org/0000-0002-1413-5569
(2007)
Effect of high-dose iron supplements on fractional zinc absorption and status in pregnant women.
American Journal of Clinical Nutrition, 85 (1).
pp. 131-136.
ISSN 0002-9165
Abstract
Background: Women have an increased risk of iron deficiency during pregnancy because of the demands of the developing fetus. Iron supplements are commonly advocated as a prophylactic treatment and are generally taken with meals to reduce side effects, but iron can interfere with the absorption of zinc. Objective: The aim was to determine the effect of consuming an iron supplement (100 mg Fe/d as ferrous gluconate) with meals from 16 wk gestation to term on zinc status and absorption. Design: Stable-isotope techniques were used to measure zinc status (exchangeable zinc pool, EZP) and fractional zinc absorption (FZA) in early and late pregnancy from a meal consumed at a different time from that of iron supplement or placebo consumption in 6 women given iron supplements and 7 given a placebo. Results: FZA increased during pregnancy, independent of iron supplementation. FZA was significantly higher (P < 0.001) at week 34 than at weeks 16 and 24, and urinary zinc excretion was higher at week 34 than at week 16 (P = 0.02). The size of the EZP remained unchanged throughout pregnancy and was unaffected by iron supplementation. The iron status of iron-supplemented women was higher than that of the placebo group. Conclusions: In iron-replete pregnant women who consumed a Western diet, no detectable adverse effects on zinc metabolism were observed after ingestion of 100 mg Fe/d. An increase in the efficiency of zinc absorption was observed during late pregnancy.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Chemistry |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Centres > Population Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 29 Jul 2014 12:24 |
| Last Modified: | 06 Jun 2024 14:49 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/49138 |
| DOI: | 10.1093/ajcn/85.1.131 |
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