Tools
Tools
Becker, Christoph, Watson, Alastair J 
ORCID: https://orcid.org/0000-0003-3326-0426 and Neurath, Markus F
(2013)
Complex roles of caspases in the pathogenesis of inflammatory bowel disease.
Gastroenterology, 144 (2).
pp. 283-93.
ISSN 0016-5085
Abstract
Caspases are cysteine proteases that regulate embryonic development, cell differentiation, tissue homoeostasis, and removal of damaged and harmful cells from the intestine and other parts of the body. Caspase activity is mainly regulated at the posttranslational level, which allows their rapid activation and response to cellular stress and pathogenic stimuli. In most cell types, caspases are initially expressed as inactive proenzymes, which undergo proteolytic cleavage to become functional enzymes. Caspase dysfunction has been associated with intestinal diseases, including inflammatory bowel disease (IBD) and colorectal cancer. Although the roles of caspases have been studied extensively in regulation of apoptosis, recent discoveries have highlighted cell death-independent functions of this protein family. In particular, caspase-1, caspase-4, caspase-5, and caspase-12 are activated during innate immune responses and participate in the formation of the inflammasome. Caspase-8 controls necroptosis of Paneth cells and potentially the death of intestinal epithelial cells in patients with Crohn's disease and appears to be involved in mucosal inflammation. Regulators of caspase-8 might therefore be used to prevent cell death in patients with IBD. Improving our understanding of the regulation and function of caspases in the intestine might lead to new therapeutics for chronic intestinal inflammation and inflammation-associated cancer.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved. |
| Uncontrolled Keywords: | caspases,humans,immunity, cellular,inflammatory bowel diseases,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology |
| Depositing User: | Pure Connector |
| Date Deposited: | 07 Jul 2014 14:02 |
| Last Modified: | 21 Aug 2023 00:25 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/48983 |
| DOI: | 10.1053/j.gastro.2012.11.035 |
Actions (login required)
 |
View Item |