Systematic review evaluating cardiovascular events of the 5-alpha reductase inhibitor - Dutasteride

Loke, Y K, Ho, R, Smith, M, Wong, O, Sandhu, M, Sage, W and Singh, S (2013) Systematic review evaluating cardiovascular events of the 5-alpha reductase inhibitor - Dutasteride. Journal of Clinical Pharmacy and Therapeutics, 38 (5). pp. 405-415. ISSN 1365-2710

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Abstract

A recently published large, long-term randomized controlled trial (RCT) brought into question the safety of dutasteride after a significantly increased risk of 'cardiac failure' was noted in the dutasteride arm of the trial compared with placebo. Our objective was to perform a meta-analysis to assess the risk of cardiovascular adverse events with the use of dutasteride for the prevention or treatment of prostatic disease.

Item Type:	Article
Additional Information:	© 2013 John Wiley & Sons Ltd.
Uncontrolled Keywords:	5-alpha reductase inhibitors,azasteroids,cardiovascular diseases,double-blind method,drug-related side effects and adverse reactions,humans,male,prostatic diseases,randomized controlled trials as topic,risk,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health (former - to 2025) Faculty of Medicine and Health Sciences > Research Centres > Mental Health and Social Care (fka Lifespan Health) Faculty of Medicine and Health Sciences > Research Centres > Public Health
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:50
Last Modified:	30 Jul 2025 09:52
URI:	https://ueaeprints.uea.ac.uk/id/eprint/48927
DOI:	10.1111/jcpt.12080

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