Redox regulation in Bacillus subtilis: The bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-Bacillithiolated OhrR and MetE

Gaballa, Ahmed, Chi, Bui Khanh, Roberts, Alexandra A., Becher, Dörte, Hamilton, Christopher, Antelmann, Haike and Helmann, John D. (2014) Redox regulation in Bacillus subtilis: The bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-Bacillithiolated OhrR and MetE. Antioxidants & Redox Signaling, 21 (3). pp. 357-367. ISSN 1523-0864

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Abstract

In bacillithiol (BSH)-utilizing organisms, protein S-bacillithiolation functions as a redox switch in response to oxidative stress and protects critical Cys residues against overoxidation. In Bacillus subtilis, both the redox-sensing repressor OhrR and the methionine synthase MetE are redox controlled by S-bacillithiolation in vivo. Here, we identify pathways of protein de-bacillithiolation and test the hypothesis that YphP(BrxA) and YqiW(BrxB) act as bacilliredoxins (Brx) to remove BSH from OhrR and MetE mixed disulfides.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Pure Connector
Date Deposited:	11 Jun 2014 13:00
Last Modified:	25 Sep 2024 11:16
URI:	https://ueaeprints.uea.ac.uk/id/eprint/48637
DOI:	10.1089/ars.2013.5327

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