Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

Wen, Shijun, Carey, Krystle L., Nakao, Yoichi, Fusetani, Nobuhiro, Packham, Graham and Ganesan, A. ORCID: https://orcid.org/0000-0003-4862-7999 (2007) Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue. Organic Letters, 9 (6). pp. 1105-1108. ISSN 1523-7060

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Abstract

The unprecedented diastereoselective Mannich reaction of a Z-allylsulfoximine was a key step in the total synthesis of the marine natural products azumamide A and E, and an unnatural analogue. Their relative potency as histone deacetylase inhibitors was evaluated and found to correlate with predicted zinc-binding affinity.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Pure Connector
Date Deposited:	11 Jun 2014 13:04
Last Modified:	25 Sep 2024 11:15
URI:	https://ueaeprints.uea.ac.uk/id/eprint/48563
DOI:	10.1021/ol070046y

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