Synthesis of N-acyl-N,O-acetals mediated by titanium ethoxide

Li, Min, Luo, Bingling, Liu, Qi, Hu, Yumin, Ganesan, A. ORCID:, Huang, Peng and Wen, Shijun (2014) Synthesis of N-acyl-N,O-acetals mediated by titanium ethoxide. Organic Letters, 16 (1). pp. 10-13. ISSN 1523-7060

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N-Acyl-N,O-acetals are present in a number of bioactive natural products, and this unusual functional group can act as a synthetic precursor to unstable reactive N-acylimines. In this paper, a variety of N-acyl-O-ethyl-N,O-acetals was concisely prepared under mild conditions mediated by titanium ethoxide (Ti(OEt)4). The method also offers a new strategy to make other O-alkyl-N,O-acetals. Furthermore, this strategy was extended to the synthesis of an analogue of the natural product turtschamide.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017)
Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User: Pure Connector
Date Deposited: 11 Jun 2014 13:00
Last Modified: 16 Apr 2024 13:30
DOI: 10.1021/ol4031155

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