Synthesis of N-acyl-N,O-acetals mediated by titanium ethoxide

Li, Min, Luo, Bingling, Liu, Qi, Hu, Yumin, Ganesan, A., Huang, Peng and Wen, Shijun (2014) Synthesis of N-acyl-N,O-acetals mediated by titanium ethoxide. Organic Letters, 16 (1). pp. 10-13. ISSN 1523-7060

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Abstract

N-Acyl-N,O-acetals are present in a number of bioactive natural products, and this unusual functional group can act as a synthetic precursor to unstable reactive N-acylimines. In this paper, a variety of N-acyl-O-ethyl-N,O-acetals was concisely prepared under mild conditions mediated by titanium ethoxide (Ti(OEt)4). The method also offers a new strategy to make other O-alkyl-N,O-acetals. Furthermore, this strategy was extended to the synthesis of an analogue of the natural product turtschamide.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Pure Connector
Date Deposited:	11 Jun 2014 13:00
Last Modified:	15 Oct 2025 03:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/48561
DOI:	10.1021/ol4031155

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