Encapsulation of drug molecules into Calix[n]arene Nanobaskets. Role of Aminocalix[n]arenes in biopharmaceutical field

Ukhatskaya, E.V., Kurkov, S.V., Matthews, S.E. and Loftsson, T. (2013) Encapsulation of drug molecules into Calix[n]arene Nanobaskets. Role of Aminocalix[n]arenes in biopharmaceutical field. Journal of Pharmaceutical Sciences, 102 (10). pp. 3485-3512. ISSN 0022-3549

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Abstract

Calix[n]arenes (CAs) are supramolecular compounds able to form guest-host inclusion complexes with metal ions, small organic molecules, and small moieties of larger molecules. Although the CA literature is extensive, relatively few publications deal with water-soluble CAs, especially those containing nitrogen-based functionality. These CAs possess antibacterial and antifungal activity. Because of their molecular structure, they are surface active and also able to form water-soluble drug complexes, giving additional potential as enabling pharmaceutical excipients. This article provides an overview of the published data regarding synthesis, physicochemical properties, and pharmaceutical application of water-soluble CAs with emphasis on those that contain nitrogen-based substituents in their structure, particularly aminoCAs. In particular, it describes state-of-the-art in complexation of water-soluble CAs with pharmaceutically relevant ions and organic molecules up to amino acids, DNA, and proteins.

Item Type: Article
Uncontrolled Keywords: antiinfectives,calixarene,complexation,excipients,inclusion compounds,interaction,nanoparticles,structure-activity relationship,surfactants
Faculty \ School:
Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: Pure Connector
Date Deposited: 12 May 2014 16:12
Last Modified: 31 Oct 2019 14:23
URI: https://ueaeprints.uea.ac.uk/id/eprint/48411
DOI: 10.1002/jps.23681

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